Yan Zeng, Ph.D.
Assistant Professor of Pharmacology
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Publications
|
Research Interests
In addition to its well-known role as a carrier of genetic
information, RNA also has structural, catalytic, and regulatory
functions. Much of my current research is focused on a class
of regulatory RNAs called microRNAs, or miRNAs. Approximately
22 nucleotides long, these RNAs are widespread and abundant
in multicellular organisms. By regulating the expression
of their many target mRNAs via RNA interference and related
mechanisms, miRNAs are able to affect a wide range of biological
processes and have exerted significant influence on the evolution
of genes. Some of the projects underway investigate: 1) how
miRNAs are differentially expressed in human cell lines and
tissues; 2) how novel miRNAs can be designed to manipulate
gene expression; and 3) how the process of RNA interference
is regulated. |
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