Jordan L. Holtzman, M.D., Ph.D.
Professor of Pharmacology & Medicine
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Publications |
Research Interests
Dr. Holtzman's laboratory has long been interested in a
variety of biochemical problems in drug metabolism and drug
toxicity. In particular, they have been concerned with the
activation of toxic agents by the cytochrome P-450 system.
They are also examining the glutathione-dependent biochemical
mechanisms whereby the cell repairs the damage produced by
toxic agents that are activated by the cytochrome P-450 system.
These studies include the purification of the protective
enzymes and their characterization by standard biochemical,
immunological, and molecular biological techniques.
Neurons have developed a complex system to maintain calcium
homeostasis. Drugs targeted to specific components of this
system are useful tools for studying signaling processes,
have profound effects on synaptic transmission and may prove
to be effective neuroprotective agents.
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