Esam El-Fakahny, Ph.D.
Professor of Psychiatry & Pharmacology
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Publications |
Research Interests
Dr. El-Fakahany's research interests are focused in the
areas of neuronal receptor modulation, mechanisms of receptor
coupling to second messenger signal transduction pathways,
and Alzheimer's disease. One of the main ongoing research
areas is the investigation of the cellular pathways that
link muscarinic acetylcholine receptors to the generation
of nitric oxide in neurons, particularly in relation to hydrolysis
of membrane phospholipids and calcium signaling. The laboratory
is also interested in elucidating the mechanisms of feedback
regulation of nitric oxide. Nitric oxide plays major roles
in the regulation of cerebral blood flow, memory and neurotoxicity.
Another area of interest is the investigation of the molecular
mechanisms of action of drugs used for the treatment of Alzheimer's
dementia. All of these questions are addressed by applying
a combination of pharmacological and molecular biology techniques
in mammalian brain, cultured neurons, or genetically engineered
cells.
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