Earl W. Dunham, Ph.D.
Associate Professor of Medicinal Chemistry & Pharmacology
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Research Interests
Dr. Dunham's research in cardiovascular pharmacology is
focused primarily on two lines of investigation that seek
to define mechanisms involved in the kidney's regulation
of blood pressure via the biosynthesis and release of vasoactive
substances. First, experiments are being conducted to determine
whether endothelial factors such as nitric oxide are responsible
for the release of an uncharacterized, hypotensive renomedullary
lipid, medullipin, that occurs upon elevation of renal perfusion
pressure.
Second, using cell culture techniques, the laboratory is
investigating endothelial cell/juxtaglomerular cell interactions
that may be involved in the control of renin release from
juxtaglomerular cells. Of particular interest are studies
concerning mechanisms whereby endothelial cell-derived factors
such as adenosine, nitric oxide, and endothelin modulate
renin release. |
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