Recent Publications

Cancer and infectious disease pharmacology

• Liang S, Connell GJ. Identification of specific inhibitors for a trypanosomatid RNA editing reaction. RNA. 2010 Dec;16(12):2435-41.
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• Peng G, Sun D, Rajashankar KR, Qian Z, Holmes KV, Li F. Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10696-701.
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• Jing Y, Lu H, Wu K, Subramanian IV, Ramakrishnan S. Inhibition of ovarian cancer by RGD-P125A-endostatin-Fc fusion proteins. Int J Cancer. 2011 Aug 1;129(3):751-61
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• Hagan CR, Regan TM, Dressing GE, Lange CA. ck2-Dependent Phosphorylation of Progesterone Receptors (PR) on Ser81 Regulates PR-B Isoform-Specific Target Gene Expression in Breast Cancer Cells. Mol Cell Biol. 2011 Jun;31(12):2439-52.
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• Becker MA, Ibrahim YH, Cui X, Lee AV, Yee D. The IGF pathway regulates ERa through a S6K1-dependent mechanism in breast cancer cells. Mol Endocrinol. 2011 Mar;25(3):516-28.
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Genome stability, transcription and RNA-based control, cell fate

• Song KY, Choi HS, Law PY, Wei LN, Loh HH. Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F. Cell Mol Life Sci. 2011 Jul 8. [Epub ahead of print]
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• Choe CY, Dong J, Law PY, Loh HH. Differential gene expression activity among species-specific polypyrimidine/polypurine motifs in mu opioid receptor gene promoters. Gene. 2011 Jan 15;471(1-2):27-36.
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• Chuang YS, Huang WH, Park SW, Persaud SD, Hung CH, Ho PC, Wei LN. Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter. Stem Cells. 2011 Apr;29(4):660-9.
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• Ho PC, Chang KC, Chuang YS, Wei LN. Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production. FASEB J. 2011 May;25(5):1758-66
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• Zhang X, Zeng Y. The terminal loop region controls microRNA processing by Drosha and Dicer. Nucleic Acids Res. 2010 Nov 1;38(21):7689-97.
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Drug addiction: mechanism, pharmacology, toxicity and treatment

• Qiu Y, Wang Y, Law PY, Chen HZ, Loh HH. Cholesterol Regulates µ-Opioid Receptor-Induced {beta}-Arrestin 2 Translocation to Membrane Lipid Rafts. Mol Pharmacol. 2011 Jul;80(1):210-8.
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• Roloff AM, Anderson GR, Martemyanov KA, Thayer SA. Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity. J Neurosci. 2010 Feb 24;30(8):3072-81
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• Arora D, Haluk DM, Kourrich S, Pravetoni M, Fernández-Alacid L, Nicolau JC, Luján R, Wickman K. Altered neurotransmission in the mesolimbic reward system of Girk mice. J Neurochem. 2010 Sep 1;114(5):1487-97.
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• Wang J, Ma J, Charboneau R, Barke R, Roy S. Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling. J Biol Chem. 2011 Mar 25;286(12):10225-32.
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• Zhong Y, Carmella SG, Upadhyaya P, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami D, Wang J, Zimmerman C, Hecht SS. Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides. Chem Res Toxicol. 2011 Feb 18;24(2):246-52.
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Drug discovery and development

• Oppegard LM, Streck KR, Rosen JD, Schwanz HA, Drlica K, Kerns RJ, Hiasa H. Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Antimicrob Agents Chemother. 2010 Jul;54(7):3011-4.
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• Kao JH, Chen SL, Ma HI, Law PY, Tao PL, Loh HH. Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm. J Pharmacol Exp Ther. 2010 Sep 1;334(3):739-45.
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• Clouser CL, Holtz CM, Mullett M, Crankshaw DL, Briggs JE, Chauhan J, VanHoutan IM, Patterson SE, Mansky LM. Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine. PLoS One. 2011 Jan 14;6(1):e15840.
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• Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS. N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of µ/kappa-opioid heteromers. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5098-103.
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• Staake M, Chauhan J, Zhou D, Shanker A, De Chatterjee A, Das S, Patterson SE. Phosphonoxins III: synthesis of a-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activity. Org Lett. 2010 Oct 15;12(20):4596-9.
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Neurological diseases, neuronal function

• Ghosh B, Li Y, Thayer SA. Inhibition of the plasma membrane Ca2+ pump by CD44 receptor activation of tyrosine kinases increases the action potential afterhyperpolarization in sensory neurons. J Neurosci. 2011 Feb 16;31(7):2361-70
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• Wei LN. The RNA superhighway: axonal RNA trafficking of kappa opioid receptor mRNA for neurite growth. Integr Biol (Camb). 2011 Jan 11;3(1):10-6.
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• Posokhova E, Wydeven N, Allen KL, Wickman K, Martemyanov KA. RGS6/Gß5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Circ Res. 2010 Nov 26;107(11):1350-4.
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• Butterick TA, Igbavboa U, Eckert GP, Sun GY, Weisman GA, Müller WE, Wood WG. Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. Mol Neurobiol. 2010 Jun;41(2-3):384-91.
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• Lockridge A, Yuan LL. Spatial learning deficits in mice lacking A-type K(+) channel subunits. Hippocampus. 2010 Sep 20. doi: 10.1002/hipo.20877. [Epub ahead of print]
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Signal transduction: regulation of intracellular second messengers, ion channels and metabolism

• Zheng H, Chu J, Zhang Y, Loh HH, Law PY. Modulating µ-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. J Biol Chem. 2011 Apr 8;286(14):12724-33.
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• Diambra L, Marchant JS. Inositol (1,4,5)-trisphosphate receptor microarchitecture shapes Ca2+ puff kinetics. Biophys J. 2011 Feb 16;100(4):822-31.
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• Ghosh B, Li Y, Thayer SA. Inhibition of the plasma membrane Ca2+ pump by CD44 receptor activation of tyrosine kinases increases the action potential afterhyperpolarization in sensory neurons. J Neurosci. 2011 Feb 16;31(7):2361-70.
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• Jude JA, Solway J, Panettieri RA Jr, Walseth TF, Kannan MS. Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010 Dec;299(6):L879-90.
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• Xie K, Allen KL, Kourrich S, Colón-Saez J, Thomas MJ, Wickman K, Martemyanov KA. Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nat Neurosci. 2010 Jun;13(6):661-3.
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