PHCL4001: Mechanisms of
Drug Action
Fall Semester Lec: Tuesdays and Thursdays, 10:10-11:00 AM
Minneapolis Campus
(2 credits; Pre-req: college level biology, biochemistry recommended; A-F only.)
Course directors:
Dr. Greg Connell (624-3132), gconnell@lenti.med.umn.edu
http://www.pharmacology.med.umn.edu/staffconnell.html
Dr. Daniel Romero (624-8997), romer002@tc.umn.edu
http://www.pharmacology.med.umn.edu/staffromero.html
Text: “Pharmacology Drug Actions and Reactions” Ruth
R. Levine, 7th Edition, Parthenon Publishing (2004)
A few of the lectures and classroom discussions will focus on
the following journal articles:
1. Hanahan, D., and R.A. Weinberg (2000). The hallmarks of cancer. Cell 100,
57-70.
2. Druker et al. (1996). Effects of a specific inhibitor of the
Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nature
Medicine 2, 561-566.
3. Druker et al. (2001). Efficacy and safety of a specific inhibitor
of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia. The
New England Journal of Medicine 344, 1031-1037.
4. Shah, N.P. et al. (2004). Overriding Imatinib Resistance with
a Novel ABL Kinase
Inhibitor. Science 305: 399-401.
COURSE SYLLABUS (Fall 2006)
Download .pdf syllabus
DATE |
LECTURE TOPIC |
*READING |
Sept. 5 (Tu)
|
Introduction |
----- |
| Sept. 7 (Th) |
Toward a greater target specificity, part 1: The cell cycle |
----- |
| Sept. 12 (Tu) |
Toward a greater target specificity, part 2: Transcriptional
regulation |
----- |
| Sept. 14 (Th) |
Toward a greater target specificity, part 3: Signal transduction |
----- |
| Sept. 19 (Tu) |
Potential drug targets; review of assigned journal article
#1 |
Journal article 1 |
| Sept. 21 (Th) |
How to develop a novel drug |
Chapter 16 |
| Sept. 26 (Tu) |
How drugs act on the living organism |
Chapter 3 |
| Sept. 28 (Th) |
Review of assigned journal article 2 |
Journal article 2 |
| Oct. 3 (Tu) |
MIDTERM EXAM 1 |
----- |
| Oct. 5 (Th) |
How drugs reach their site of action – biotransport |
Chapter 4 |
| Oct. 10 (Tu) |
How drugs reach their site of action – distribution |
Chapter 6 |
| Oct. 12 (Th) |
How drugs reach their site of action – absorption |
Chapter 5 |
| Oct. 17 (Tu) |
Termination of drug action – Inactivation by the liver |
Chapter 8 |
| Oct. 19 (Th) |
Termination of drug action – Excretion by the kidney |
Chapter 7 |
| Oct. 24 (Tu) |
Determining drug dosage |
Chapters 9, 10 |
Oct. 26 (Th) |
Determining drug toxicity |
Chapters 10, 13 |
| Oct. 31 (Tu) |
Review of journal article 3 and assignment #1 |
Journal article 3 |
| Nov. 2 (Th) |
MIDTERM EXAM 2 |
----- |
| Nov. 7 (Tu) |
Factors modifying drug effects in individuals |
Chapter 11/12 |
| Nov. 9 (Th) |
Pharmacogenetics/Pharmacogenomics |
----- |
| Nov. 14 (Tu) |
Pharmacogenetics/Pharmacogenomics |
----- |
| Nov. 16 (Th) |
The significance of drug interactions |
----- |
| Nov. 21 (Tu) |
Mechanisms of drug resistance; review assigned article 4 |
Journal article 4 |
| Nov. 23 (Th) |
THANKSGIVING |
----- |
| Nov. 28 (Tu) |
Immunology and Cancer |
|
| Nov. 30 (Th) |
Palliative treatment/pain management |
Chapter 15 |
| Dec. 5 (Tu) |
Review assigned journal article 5 |
Journal article 5 |
| Dec. 7 (Th) |
MIDTERM EXAM 3 |
----- |
Assigned chapters are in Levine (7th Ed.). Journal articles are
indicated on the previous pages and on the course website.
|
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