2007 Pharmacology Seminar Series

Spring Fall

Spring 2007

January 5
Aging and Alzheimer's Disease are Due to Declines in Protein Processing in the Endoplasmic Reticulum
JORDAN HOLTZMAN, M.D. , Ph.D.
Departments of Pharmacology and Medicine and the
Division of Environmental Health Sciences
University of Minnesota

January 12
Specific delivery of siRNA and multiple therapeutics to ailing cells using RNA nanotechnology and phi29 motor components
PEIXUAN GUO , Ph.D.
Professor, Molecular Virology and Biomedical Engineering
Purdue University
Hosted by: Dr. Yan Zeng (612.625.4479)

January 19
COUP-TFII, an orphan nuclear receptor, in development and disease
SOPHIA TSAI , Ph.D.
Professor, Department of Molecular and Cellular Biology
Baylor College of Medicine
Hosted by: Dr. Li-Na Wei (612.625.9402)

January 26
Statins are good for the brain: Neuroprotective mechanisms of simvastatin
W. GIBSON WOOD, Ph.D.
Associate Director (E/E) and Professor
Geriatric Research, Education and Clinical Center
VAMC and Department of Pharmacology
University of Minnesota School of Medicine

February 16
Fluorescence-Detected Protein Trafficking into and out of the ER
ARTHUR JOHNSON , Ph.D.
Wehner-Welch Chair and Distinguished Professor
Department of Chemistry and Molecular & Cellular Medicine
Texas A&M College of Medicine
Hosted by: Dr. Jordan Holtzman (612.626.9822)

February 23
Progress in the Neurodegenerative Diseases: Innovative Science, Emerging Therapeutics and Clinical Challenges
JEFF VAUGHT , Ph.D.
Executive Vice President, Research and Development
Cephalon, Inc.
Hosted by: Dr. George Wilcox (612.625.1474)

CANCELLED
~~March 9~~
Title: TBA
KARL WEISGRABER , Ph.D.
Senior Investigator, Gladstone Institute of Neurological Disease
Professor, Department of Pathology
University of California, San Francisco
Hosted by: Dr. Gibson Wood (612.467.3303)

March 23
Regulation of Retinoid Metabolic Pathways
A. CATHERINE ROSS , Ph.D.
Professor, Department of Nutritional Sciences
Pennsylvania State University
Hosted by: Dr. Li-Na Wei (612.625.9402)

THURSDAY, April 5
2006 F.E. SHIDEMAN-STERLING ANNUAL LECTURE
Building molecules to spy on cells and tumors
ROGER Y. TSIEN, Ph.D.
Professor, Department of Pharmacology
University of California, San Diego
Hosted by: Dr. Horace Loh (612.626.4460)

CANCELLED ~~April 6~~
Inverse Agonism at the Cannabinoid CB1 Receptor and Its Therapeutic Promise
PATRICIA H. REGGIO, Ph.D.
Marie Foscue Rourk Professor and Head
Department of Chemistry and Biochemistry
University of North Carolina
Hosted by: Dr. Ping-Yee Law (612.626.6497)

April 20
Regulation of Striatal Gene Expression in Health and Disease
MICHELLE EHRLICH, M.D.
Professor, Farber Institute for Neurosciences
Thomas Jefferson University
Hosted by: Dr. Kirill Martemyanov (612.626.5309)

April 27
Some assembly required: constructing the elementary units of store-operated calcium entry
RICHARD LEWIS , Ph.D.
Professor and Chair, Department of Molecular and Cellular Physiology
Stanford University School of Medicine
Hosted by: Dr. Stanley Thayer (612.626.7049)

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Fall 2007

September 7
The Butterflies of the Soul: A Target for Schizophrenia Treatment
Erminio Costa, M.D.
Scientific Director, Psychiatric Institute
Professor, Department of Biochemistry in Psychiatry
University of Chicago, IL
Hosted by: Dr. Horace Loh (612.624.4460)

September 14
Regulator of G-protein Signaling (RGS) Proteins as Novel Drug Discovery Targets
David Siderovski, Ph.D.
Associate Professor
Department of Pharmacology
University of North Carolina, Chapel Hill School of Medicine
Hosted by: Dr. Kirill Martemyanov (612.626.5309)

September 21
Inverse Agonism at the Cannabinoid CB1 Receptor and Its Therapeutic Promise
Patricia Reggio, Ph.D.
Marie Foscue Rourk Professor and Head
Department of Chemistry & Biochemistry
University of North Carolina, Greensboro
Hosted by: Dr. Ping-Yee Law (612.626.6497)
Co-sponsored by the Basic Research Center on the Molecular and Cell Biology of Drug Addiction (NIDA: DA011806)

September 28
Mu Opioid Receptor Desensitization and Trafficking in Locus Coeruleus Neurons
John Williams, Ph.D.
Senior Scientist
Vollum Institute
Oregon Health Sciences University
Hosted by: Dr. Kevin Wickman (612.624.5966)
Co-sponsored by the Basic Research Center on the Molecular and Cell Biology of Drug Addiction (NIDA: DA011806)

THURSDAY, October 4, 2:15, Mayo Auditorium
2007 F.E. SHIDEMAN-STERLING ANNUAL LECTURE
Protein Cross Talk in Cell Signaling
Edmond H. Fischer, Ph.D.
Professor Emeritus, Department of Biochemistry
University of Washington, Seattle
1992 Nobel Prize Laureate in Physiology and Medicine

Click here for a recording of Dr. Fischer's presentation.

October 19
Story of the Constitutively Activated LH Receptors: Two Fates of One Mutation
Wai-Yee Chan, Ph.D.
Head, Section on Developmental Genomics, LCG/NICHD
National Institutes of Health
Professor, Depts of Pediatrics, Biochemistry and Molecular & Cellular Biology
Georgetown University School of Medicine
Hosted by: Dr. Ping-Yee Law (612.626.6497)
Co-sponsored by the Basic Research Center on the Molecular and Cell Biology of Drug Addiction (NIDA: DA011806)

November 9
GPRC5A: A New Lung Tumor Suppressor
Reuben Lotan, Ph.D.
Irving and Nadine Mansfield and Robert David Levitt Cancer Research Chair; Deputy Division Head for Research, Division of Cancer Medicine; Director, Clinical Research Building, Department of Thoracic/Head and Neck Medical Oncology-Unit 432
M.D. Anderson Cancer Center
University of Texas
Hosted by: Dr. Li-Na Wei (612.625.9402)

November 16
The Role of the Glutatione Pathway in the Prevention of Cardiovascular Deaths: A New Risk Factor and its Therapeutic Implications
Jordan Holtzman, M.D., Ph.D.
Professor, Departments of Pharmacology and Medicine and the
Division of Environmental Health Sciences
University of Minnesota

November 30
Genetics and Pathophysiology of Huntington's Disease
Cynthia T. McMurray, Ph.D.
Professor, Departments of Pharmacology, Biochemistry and Molecular Biology
Mayo Clinic, Rochester
Hosted by: Dr. Stan Thayer (612.626.7049)

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